MT-1

MT-1

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€40.00

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Research Use Only: These products are intended for laboratory research purposes only. By purchasing, you confirm you are a qualified researcher and understand this product is not for personal use.
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Description

MT-1 (Melanotan I), also known as afamelanotide, is a synthetic version of alpha-MSH — the body’s natural pigmentation-controlling hormone — with two structural modifications that make it bind more strongly to its receptor and last longer in the body. It works by activating melanocytes, the skin cells responsible for producing melanin, the pigment that gives skin its colour and provides protection against UV radiation. It is one of the most extensively studied melanocortin receptor agonists in dermatological research.

What the research has found

• Clinical studies in patients with erythropoietic protoporphyria — a rare genetic condition causing severe light sensitivity — showed that afamelanotide implants significantly increased the amount of pain-free time patients could spend in sunlight compared to placebo. Skin biopsies confirmed substantially increased melanin content in the epidermis, validating the mechanism (Harms et al., 2009)

• In vitro studies demonstrated MT-1 stimulates melanin production in cultured melanocytes at concentrations approximately 100 times lower than native α-MSH, consistent with its much stronger receptor binding affinity conferred by the structural modifications (Hartmeyer et al., 1999)

• Research examining differences in melanocortin-1 receptor (MC1R) variants — which are common genetic variations affecting natural tanning ability — showed differential melanin production responses to MT-1 depending on the receptor variant present, making it a useful research tool for studying the functional consequences of MC1R genetics (Hadley & Dorr, 2006)

• Beyond pigmentation, MT-1 also binds MC3R and MC4R receptors, opening research directions into its effects on inflammation, energy regulation, and pain signalling (Hartmeyer et al., 1999)

For research use only. Not intended for use in humans or animals.

References
Hadley, M. E., & Dorr, R. T. (2006). https://pubmed.ncbi.nlm.nih.gov/16472303/
Harms, J., et al. (2009). https://pubmed.ncbi.nlm.nih.gov/19587338/
Hartmeyer, M., et al. (1999). https://pubmed.ncbi.nlm.nih.gov/10384685/

Additional information

Size

10mg/vial

What are peptides?

Peptides are short chains of amino acids that act as signalling molecules in the body, playing a role in a wide range of biological processes including tissue repair, immune response, and cellular communication.

How are peptides used in research?

In research settings, peptides are studied for their ability to interact with specific receptors and biological pathways. This makes them valuable tools for scientific and laboratory analysis, helping researchers better understand how the body functions at a cellular level.

What payment methods do you accept?

We currently accept Credit Card, SEPA bank transfer, iDeal, Google Pay, Apple Pay, and Cryptocurrency (Bitcoin, Ethereum, and USDT).

How should I store my peptides?

All peptides are supplied in lyophilised (freeze-dried) form, ensuring stability during shipping and long-term storage. Unreconstituted vials should be kept in a cool, dry place away from direct light, with refrigeration recommended for extended periods. Once reconstituted for research purposes, peptides should be kept refrigerated and handled using sterile laboratory practices to maintain integrity throughout use.

How does shipping and delivery work?

Orders are processed and dispatched within 2 weeks of purchase. Shipping takes 48 hours through UPS Express Shipping. Order tracking is available directly on our website. Free shipping is applied automatically on all orders over €180.

Do you offer refunds or returns?

Due to the nature of research products, we are unable to accept returns. However if your order arrives damaged or incorrect please contact us within 48 hours.

How can I be sure of product quality?

All our products are lab-tested to ensure high purity and compliance with research-grade quality standards.

Lab-Verified
Certificate of Analysis for MT-1
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MT-1 (Melanotan I), also known as afamelanotide, is a synthetic version of alpha-MSH — the body’s natural pigmentation-controlling hormone — with two structural modifications that make it bind more strongly to its receptor and last longer in the body. It works by activating melanocytes, the skin cells responsible for producing melanin, the pigment that gives skin its colour and provides protection against UV radiation. It is one of the most extensively studied melanocortin receptor agonists in dermatological research.

What the research has found

• Clinical studies in patients with erythropoietic protoporphyria — a rare genetic condition causing severe light sensitivity — showed that afamelanotide implants significantly increased the amount of pain-free time patients could spend in sunlight compared to placebo. Skin biopsies confirmed substantially increased melanin content in the epidermis, validating the mechanism (Harms et al., 2009)

• In vitro studies demonstrated MT-1 stimulates melanin production in cultured melanocytes at concentrations approximately 100 times lower than native α-MSH, consistent with its much stronger receptor binding affinity conferred by the structural modifications (Hartmeyer et al., 1999)

• Research examining differences in melanocortin-1 receptor (MC1R) variants — which are common genetic variations affecting natural tanning ability — showed differential melanin production responses to MT-1 depending on the receptor variant present, making it a useful research tool for studying the functional consequences of MC1R genetics (Hadley & Dorr, 2006)

• Beyond pigmentation, MT-1 also binds MC3R and MC4R receptors, opening research directions into its effects on inflammation, energy regulation, and pain signalling (Hartmeyer et al., 1999)

For research use only. Not intended for use in humans or animals.

References
Hadley, M. E., & Dorr, R. T. (2006). https://pubmed.ncbi.nlm.nih.gov/16472303/
Harms, J., et al. (2009). https://pubmed.ncbi.nlm.nih.gov/19587338/
Hartmeyer, M., et al. (1999). https://pubmed.ncbi.nlm.nih.gov/10384685/

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